2026

Learnable frozen feature augmentation for few-shot biomarker prediction from pathology whole-slide images

Learnable frozen feature augmentation for few-shot biomarker prediction from pathology whole-slide images

Reliable biomarker labels are often scarce in computational pathology, making label-efficient whole-slide image prediction difficult. LFFA introduces a training-time feature-space augmentation framework for frozen slide-level foundation model pipelines, learning controllable augmented slide views that preserve semantic consistency while improving representation diversity. Across three few-shot biomarker prediction tasks and multiple foundation-model backbones, it improves robustness over existing augmentation methods.

Recommended citation: D Zhang, J Liu, Y Ma, J Ge, Z Zeng, W Sun, Q Liu, K He, Y Zheng, W Yu, C Li*, Z Gao*. Learnable frozen feature augmentation for few-shot biomarker prediction from pathology whole-slide images. Bioinformatics, 2026, btag597.
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