StaDis: Stability distance to detecting out-of-distribution data in computational pathology

Computational pathology models can fail silently when they encounter out-of-distribution data that differ from the training distribution. StaDis introduces a plug-and-play OOD detection method tailored to this setting by measuring the feature gap between an image and its perturbed counterpart. Without retraining the underlying predictor, it improves deployment safety and helps flag unreliable predictions in real clinical environments.
Recommended citation: Zhang D, Ge J, Liu J, Wang C, Gong T, Gao Z*, Li C*. StaDis: Stability distance to detecting out-of-distribution data in computational pathology. Medical Image Analysis. 2025 Aug 27:103774.
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